Award
National Institute of Diabetes and Digestive and Kidney Diseases 5K08DK140612-03
Endoplasmic Reticulum Stress Controls Innate Lymphoid Cells in Intestinal Inflammation
Recipient
Washington University
Award Amount
$166,584.00
Ceiling
$166,584.00
Awarded
May 05, 2026
Identifier
5K08DK140612-03
NIH awarded a research project to study the role of endoplasmic reticulum stress in innate lymphoid cells related to inflammatory bowel disease, led by Dr. Siyan Cao at Washington University, with a total funding of $166,584.
Description
The project focuses on the mechanistic role of IRE1α-XBP1-mediated endoplasmic reticulum stress in innate lymphoid cells and their implications in inflammatory bowel disease. The research involves multicellular organoid culture, mouse models, and human samples. The project aims to elucidate pathways that may serve as novel response biomarkers in inflammatory bowel disease.