Award
National Institute of Diabetes and Digestive and Kidney Diseases 1R01DK144476-01
Cellular Senescence and the AKI to CKD transition
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$1,491,303.00
Ceiling
$1,491,303.00
Awarded
September 05, 2025
Identifier
1R01DK144476-01
Research project funded by NIDDK to study cellular senescence in kidney injury and disease progression, focusing on Foxm1 and CCNF roles.
Description
This project aims to identify cellular senescence as a driver of failed renal repair and the molecular mechanisms underlying this process to define areas for therapeutic intervention in acute kidney injury (AKI) transitioning to chronic kidney disease (CKD). The research focuses on the role of Foxm1, a master regulator of the cell cycle, and its target cyclin F (CCNF), in tubular epithelial proliferation and senescence.