Award
National Institute of Allergy and Infectious Diseases 5R01AI147630-05
Manipulation of the host cell inflammasome by Mycobacterium tuberculosis
Recipient
University of Maryland, College Park, MD
Award Amount
$592,882.00
Ceiling
$592,882.00
Awarded
May 28, 2026
Identifier
5R01AI147630-05
The award supports research on how Mycobacterium tuberculosis suppresses host cell inflammasome activation to evade immune response, potentially leading to new therapeutic targets for tuberculosis.
Description
This project aims to characterize how Mycobacterium tuberculosis inhibits the activation of the NLRP3 and AIM2 inflammasomes, identify the specific Mtb genes involved (including PknF), and understand the molecular mechanisms of this inhibition. The findings could lead to new targets for adjunctive Mtb drugs and host-directed therapeutics.