Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK127625-06
Urotensin II and renal insufficiency in growth-restricted infants.
Recipient
University of Missouri-Columbia
Award Amount
$592,319.00
Ceiling
$592,319.00
Awarded
August 01, 2024
Identifier
5R01DK127625-06
Research grant investigating Urotensin II's role in kidney injury in growth-restricted infants using a porcine model to find therapeutic targets.
Description
This project investigates the role of Urotensin II (UII), a potent vasoactive peptide, in contributing to renal insufficiency in growth-restricted newborns. UII stimulates peripheral sympathoexcitation, which triggers kidney injury in neonates. The study will use a preclinical porcine model of naturally-occurring human asymmetric IUGR to elucidate the mechanisms involved and identify potential therapeutic targets.