Award
National Institute of Allergy and Infectious Diseases 5P01AI181898-03
Project 3 Determinants of Vaccine Efficacy
Recipient
UNIV OF MASSACHUSETTS MED SCH WORCESTER
Award Amount
$470,732.00
Ceiling
$470,732.00
Awarded
June 10, 2026
Identifier
5P01AI181898-03
Research project to understand and improve tuberculosis vaccine efficacy through genetic and immunological studies across multiple species and human clinical trials.
Description
The project focuses on understanding the determinants of vaccine efficacy against tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb). It aims to analyze genetic and immunological factors influencing vaccine responses, evaluate new vaccine strategies, and identify correlates of protection across species, including humans, mice, and non-human primates. The study leverages genetic diversity in mouse models and clinical samples from South Africa to improve TB vaccine evaluation and uncover mechanisms of vaccine-induced immunity.