Award
NIH Reporter #5UH3DA056880-03
Identifying optimal buprenorphine dosing for OUD treatment and prevention of overdose
Recipient
Brown University, Providence, RI, United States
Award Amount
$508,750.00
Ceiling
$508,750.00
Awarded
February 18, 2026
Identifier
5UH3DA056880-03
A research project funded by the National Institute on Drug Abuse to determine the optimal buprenorphine dosing for treating opioid use disorder in patients using fentanyl, involving a mixed method study and a randomized controlled trial to improve treatment outcomes and reduce overdose risk.
Description
This project aims to evaluate the optimal buprenorphine maintenance treatment dose for patients with opioid use disorder (OUD) who have a history of fentanyl use. It involves a mixed method study to assess the association between buprenorphine dose and overdose occurrence, followed by a randomized controlled trial comparing standard versus high dose maintenance protocols. The study will provide data to inform best clinical practices for OUD treatment.