Award
NIH Reporter #1K01DK147652-01
Investigating Mitochondrial DNA as a Biomarker and Therapeutic Target in Chronic Kidney Disease
Recipient
University of California, San Diego
Award Amount
$148,596.00
Ceiling
$148,596.00
Awarded
May 28, 2026
Identifier
1K01DK147652-01
Research project to establish cf-mtDNA as a biomarker for kidney and vascular dysfunction in CKD and evaluate NR as a therapeutic strategy.
Description
This project aims to investigate the relationship between circulating and urinary cell-free mitochondrial DNA (cf-mtDNA) levels and systemic microvascular health in individuals with chronic kidney disease (CKD). It will evaluate whether cf-mtDNA can serve as an early biomarker of kidney and vascular dysfunction and assess the feasibility of nicotinamide riboside (NR) supplementation as a therapeutic strategy.