Award
National Institute of Mental Health 5R01MH120162-07
Circuit Mechanisms of Retrospective Memory-Linking
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY, UNITED STATES
Award Amount
$599,024.00
Ceiling
$599,024.00
Awarded
March 19, 2026
Identifier
5R01MH120162-07
This award funds research to understand how aversive memories link to past neutral memories through hippocampal activity during offline periods, using advanced neuroscience techniques.
Description
The project investigates the circuit mechanisms of memory linking, specifically how aversive memories retrospectively update and link to past neutral memories during post-encoding offline periods to influence future behavior, such as avoiding dangerous situations. The research involves recording and manipulating hippocampal ensemble activity during offline periods to test hypotheses about memory integration and reactivation during sharp-wave ripples (SWRs).