Award
National Cancer Institute 5U01CA284085-03
Investigating disseminated cancer cell clonal cooperation and immune control in dormancy and metastasis
Recipient
Albert Einstein College of Medicine
Award Amount
$862,065.00
Ceiling
$862,065.00
Awarded
April 21, 2026
Identifier
5U01CA284085-03
The award funds research on the cooperation between early and late disseminated cancer cells in metastasis formation and immune evasion, focusing on dormancy mechanisms and immune niche interactions in the lung to develop new therapeutic strategies.
Description
This project investigates how early disseminated cancer cells (eDCCs) and late disseminated cancer cells (L-DCCs) cooperate to initiate metastasis, evade immune surveillance, and how dormancy and reactivation mechanisms operate. The study uses genetic lineage tracing, protein barcoding, and single cell RNA sequencing to understand the molecular and immune interactions in lung metastasis, aiming to develop immune targeting approaches to eradicate dormant cancer cells and prevent metastasis.