Award
NIH Reporter #5R01DC020423-05
Mouse, Man, and Machine: Combining Model Systems to Develop a Biomarker for Cochlear Deafferentation in Humans
Recipient
Oregon Health & Science University, Portland, OR
Award Amount
$542,496.00
Ceiling
$542,496.00
Awarded
June 25, 2026
Identifier
5R01DC020423-05
NIH funded research project to develop a non-invasive diagnostic biomarker for cochlear deafferentation to improve diagnosis and treatment of auditory dysfunctions.
Description
This research aims to develop a biomarker for cochlear deafferentation, a hidden form of auditory damage that affects many individuals and is not diagnosable with current clinical tests. The project involves expanding a computational model of the auditory periphery (CMAP) to predict physiological responses, validating the model with animal data, and applying it to human subjects to estimate deafferentation levels. The goal is to enable diagnosis and targeted treatment of auditory perceptual deficits.