Award
National Institute of Allergy and Infectious Diseases 3R01AI173360-04S1
Enterovirus interference with rotavirus vaccine replication and immunity
Recipient
Washington University, Saint Louis, MO
Award Amount
$126,597.00
Ceiling
$126,597.00
Awarded
June 30, 2026
Identifier
3R01AI173360-04S1
Research project funded by NIAID to study how Enterovirus B affects rotavirus vaccine efficacy, using lab and clinical studies to improve vaccine responses in children.
Description
This project aims to elucidate the mechanisms of Enterovirus B-mediated interference with rotavirus vaccines through analyses in human intestinal organoids, mouse models, and clinical fecal samples. The research will identify antiviral signaling pathways involved, assess their impact on vaccine replication and immune response, and compare responses between infants in Ghana and the US. Outcomes will inform strategies to improve vaccine efficacy and reduce diarrheal disease burden.