Award
National Institute for Occupational Safety and Health 5R21OH012552-02
Defining the Role of IL-1? in Tungsten-Mediated Cardiovascular Disease
Recipient
University of New Mexico Health Sciences Center, Albuquerque, NM
Award Amount
$190,625.00
Ceiling
$190,625.00
Awarded
August 13, 2025
Identifier
5R21OH012552-02
The award funds research to define how chronic tungsten exposure affects cardiovascular disease development via IL-1β signaling and cardiac remodeling, aiming to identify mechanisms and potential countermeasures to mitigate risk in occupational settings.
Description
This project investigates the long-term health consequences of chronic exposure to tungsten and the underlying molecular mechanisms of toxicity, focusing on cardiovascular disease development through IL-1β signaling and cardiac remodeling leading to fibrosis. The study uses experimental designs to assess the impact of tungsten inhalation on cardiac function and disease development, including blocking IL-1β signaling to understand its role in inflammation and remodeling processes.