Award
National Heart, Lung, and Blood Institute 5K08HL173572-03
The Impact of Soluble ST2 on Lung Injury Onset and Resolution
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$170,640.00
Ceiling
$170,640.00
Awarded
May 25, 2026
Identifier
5K08HL173572-03
This NIH grant supports research on the role of soluble ST2 in lung injury and repair, particularly in ARDS, using animal models and patient data to understand immune pathways and identify therapeutic targets.
Description
The project investigates the role of IL-33 signaling and its regulation by soluble ST2 in lung injury and repair, focusing on acute respiratory distress syndrome (ARDS). It aims to define how immune regulatory pathways influence disease progression and recovery, leveraging both murine models and longitudinal human data.