# NIH Reporter #4R00HL175037-03

Unraveling Fatty Acid-driven Mechanisms of Platelet Hyper-Activation in Obesity

**Recipient:** Research Inst Nationwide Children's Hosp

**Award Amount:** $249,000.00
**Ceiling:** $249,000.00

**Awarded:** July 27, 2026

**Identifier:** 4R00HL175037-03

NIH-funded research examining how saturated dietary fats may contribute to platelet hyperreactivity in obesity, with the goal of clarifying mechanisms relevant to cardiovascular complications.

### Description

The project investigates how dietary saturated fatty acids affect platelet membrane composition, platelet reactivity, and thrombus formation in obesity. Its aims include examining fatty acid uptake and platelet membrane properties, testing effects on thrombus formation, and investigating lipid raft content and receptor signaling.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11552937)