Award
National Institute of Neurological Disorders and Stroke 5R01NS132493-04
The Role of Dendritic Cells in Regulating the Gut-Brain Immune Axis in Ischemic Stroke
Recipient
Weill Medical College of Cornell University
Award Amount
$455,141.00
Ceiling
$455,141.00
Awarded
February 19, 2026
Identifier
5R01NS132493-04
Award to Weill Medical College of Cornell University to study the role of dendritic cells and gut microbiota in stroke outcomes, aiming to develop new prevention and treatment strategies.
Description
This project investigates the immune mechanisms involved in stroke and the influence of gut microbiota, aiming to develop microbiota-based interventions for stroke prevention and therapy. The research involves mouse models of cerebral ischemia, gut bacteria alteration, immune cell tracking, and in vitro coculture models to elucidate the role of intestinal microbiota in stroke pathobiology and develop new preventative and therapeutic strategies.