Award
NIH Reporter #1R21AI190998-01A1
Defining the mechanism of CNS inflammation induced by colitis
Recipient
Loyola University Chicago, Maywood, IL
Award Amount
$423,500.00
Ceiling
$423,500.00
Awarded
February 02, 2026
Identifier
1R21AI190998-01A1
Research grant awarded to study the mechanisms by which colitis induces CNS inflammation, focusing on inflammasome activation and cell-specific responses using mouse models.
Description
This grant supports research into the mechanisms linking bowel inflammation to brain inflammation, with potential therapeutic implications for neurodegenerative diseases associated with IBD. The project aims to understand how CNS inflammation is induced by colitis, identify serum factors driving CNS inflammasome activation, and use advanced mouse models to study cell-specific impacts.