Award
National Institute of Allergy and Infectious Diseases 1F31AI197983-01
Elucidating the structural adaptation of HIV-1 capsids during critical host-factor interactions
Recipient
Florida State University
Award Amount
$42,065.00
Ceiling
$42,065.00
Awarded
April 06, 2026
Identifier
1F31AI197983-01
Research project funded by NIAID to study HIV-1 capsid structural changes during host interactions using advanced imaging techniques.
Description
The project aims to define how host proteins facilitate HIV-1 capsid transport by altering its structure to release the viral genome to integration sites. It involves structural studies of HIV-1 capsids, including cryo-electron tomography and live-cell imaging, to understand capsid remodeling during nuclear entry and integration.