Award
National Institute of Allergy and Infectious Diseases 5R21AI185820-02
mRNA-Based Vaccines Against Tick Borne Thogotoviruses
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$232,258.00
Ceiling
$232,258.00
Awarded
March 27, 2026
Identifier
5R21AI185820-02
Development of an mRNA vaccine targeting Bourbon virus and other tick-borne pathogens to create a universal vaccine platform, including efficacy testing and mechanism studies.
Description
The project aims to develop an mRNA vaccine against Bourbon virus (BRBV), evaluate its efficacy in vivo in a mouse model, and determine the mechanism of action. It also seeks to test different viral antigens and combinations to develop a roadmap for panpathogen mRNA vaccines, ultimately contributing to a universal vaccine against tick-borne pathogens.