Award
National Institute of General Medical Sciences 5R35GM150920-03
Chemical Proteomics Approach to Discover Novel Small Molecule E3 Ligase Recruiters for Targeted Protein Degradation (TPD)
Recipient
Emory University, Atlanta, GA, United States
Award Amount
$391,250.00
Ceiling
$391,250.00
Awarded
July 09, 2025
Identifier
5R35GM150920-03
This NIH grant supports research to design and validate new E3 ligase ligands for targeted protein degradation using chemoproteomic strategies, aiming to overcome current limitations in E3 ligase recruiters.
Description
The research aims to discover a new class of covalent E3 ligase recruiters using chemoproteomic approaches. The goal is to generate novel degraders that can expand the repertoire of E3 ligases and develop tissue- and disease-specific molecular degraders.