# NIH Reporter #5P50NS123067-05

Cholinergic mechanisms of attentional-motor integration and gait dysfunction in Parkinson Disease

**Recipient:** University of Michigan at Ann Arbor

**Award Amount:** $2,325,657.00
**Ceiling:** $2,325,657.00

**Awarded:** June 26, 2025

**Identifier:** 5P50NS123067-05

The University of Michigan project investigates cholinergic mechanisms underlying gait and cognitive dysfunction in Parkinson disease. It uses patient cohorts and animal models to study attentional-motor integration, gait and balance abnormalities, fall propensity, and cognitive decline.

### Description

Research project examining how cholinergic system degeneration relates to gait, balance, falls, and cognitive impairments in Parkinson disease, using neuroimaging, behavioral and physiological studies in patients and animal models.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11160597)