Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK141801-02
Liver and kidney responses to bilirubin as a nuclear receptor hormone
Recipient
Vanderbilt University Medical Center
Award Amount
$380,625.00
Ceiling
$380,625.00
Awarded
December 10, 2025
Identifier
5R01DK141801-02
Research grant awarded to study the molecular mechanisms of bilirubin's protective effects on liver and kidney diseases via nuclear receptor activation.
Description
This project investigates how bilirubin, a heme metabolite, exerts protective effects against diabetic and chronic kidney diseases through activation of Liver Receptor Homolog-1 (LRH-1, NR5A2). The study aims to elucidate the molecular mechanisms by which bilirubin levels are sensed and how nuclear receptors mediate responses in the liver and kidneys.