Award
National Heart, Lung, and Blood Institute 5R01HL163168-04
Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and Pathology
Recipient
State University of New York at Buffalo, Amherst, NY
Award Amount
$547,606.00
Ceiling
$547,606.00
Awarded
August 03, 2026
Identifier
5R01HL163168-04
The award funds research investigating how arterial stiffness affects vascular smooth muscle cell behavior and contributes to cardiovascular disease, focusing on the protein survivin as a key regulator, using advanced in vitro and in vivo models.
Description
This research explores the novel roles of survivin as a key regulator of stiffness-mediated vascular smooth muscle cell (VSMC) phenotypes, neointima formation, and arterial stiffening. It employs in vitro porcine aorta decellularized extracellular matrix-based experimental systems, single-cell analyses, and a mouse model to examine VSMC interactions with the pathological vascular environment and identify potential therapeutic targets for cardiovascular disease.