Award
Pennsylvania Department of Military and Veterans Affairs 5I01BX006454-02
Innate immunity and ischemic stroke
Recipient
Veterans Health Administration, Pittsburgh, PA, USA
Awarded
October 03, 2025
Identifier
5I01BX006454-02
Research project focused on the role of innate immunity and RNA editing in ischemic stroke, aiming to develop new therapeutic strategies targeting neuroinflammation.
Description
The project investigates the role of transposable elements (TE) in ischemic brain injury and the mechanism underlying TEs' triggering of neuroinflammation in an animal model of ischemic stroke. It aims to determine whether a novel therapy targeting ADAR1 can attenuate ischemic brain injury and improve neurological function, potentially providing a new anti-inflammatory therapy for stroke.