Award
National Cancer Institute 5R01CA282225-03
Disruption of the circadian clock in lung cancer
Recipient
University of Rochester
Award Amount
$428,791.00
Ceiling
$428,791.00
Awarded
March 30, 2026
Identifier
5R01CA282225-03
Research grant focused on understanding and potentially reversing circadian clock disruption in non-small cell lung cancer by targeting BMAL1 and MYC genes to improve tumor outcomes and treatment response.
Description
This project investigates the role of the BMAL1 gene and MYC oncogene in circadian disruption and lung cancer progression. The study aims to restore BMAL1 expression in MYC-amplified lung models and assess the impact on tumor development and response to glucocorticoids.