Award
National Institute on Aging 1R21AG084916-01A1
'Omics predictors of Sickle Cell Severity and Survival
Recipient
Duke University
Award Amount
$430,956.00
Ceiling
$430,956.00
Awarded
July 17, 2024
Identifier
1R21AG084916-01A1
A research project funded by the National Institute on Aging to identify multi-omic biomarkers predicting severity and survival in sickle cell disease, using data from large cohorts to understand aging and mortality factors.
Description
This project aims to study multi-omic markers of early mortality versus successful aging in sickle cell disease (SCD). It leverages data and biological samples from a cohort of approximately 600 individuals, as well as other cohorts totaling over 4,000 samples deposited in the NHLBI TOPMed biodata repository. The research focuses on identifying biomarkers related to aging and mortality, including telomere length, mitochondrial copy number, clonal hematopoiesis, and proteomic and glycoproteomic biomarkers.