Award
National Institute of Mental Health 5R01MH136706-03
Linking mitochondrial and synaptic weakness to schizophrenia
Recipient
Children's Hospital of Philadelphia
Award Amount
$649,499.00
Ceiling
$649,499.00
Awarded
January 21, 2026
Identifier
5R01MH136706-03
A research project funded by the National Institute of Mental Health to study mitochondrial and synaptic function in schizophrenia using IPSC-derived neurons, aiming to identify therapeutic targets.
Description
This project explores the relationship between mitochondrial function and synaptic activity in the context of schizophrenia, with potential implications for therapeutic interventions. The research involves studying mitochondrial biogenesis, mitophagy, and glutamatergic synaptic release in IPSC-derived neurons from 22qDS with or without schizophrenia and unaffected controls.