Award
National Cancer Institute 5R35CA197591-12
Integrative approaches to elucidate p53 transcriptional networks during carcinogenesis
Recipient
Stanford University
Award Amount
$927,049.00
Ceiling
$927,049.00
Awarded
June 30, 2026
Identifier
5R35CA197591-12
This NIH-funded project at Stanford University aims to elucidate the mechanisms by which the tumor suppressor gene p53 suppresses cancer, using advanced molecular and cellular techniques to identify new therapeutic targets.
Description
The research focuses on understanding the tumor suppressor gene TP53, which is mutated in over half of all human cancers. The project aims to deconstruct the pathways through which p53 suppresses cancer, identify new mechanisms of p53-mediated tumor suppression, and explore post-transcriptional regulation such as splicing and proteomics analyses. The study will utilize advanced techniques including single-cell RNA-seq, scATAC-seq, and in vivo tumor assays (Tuba-seq) in mouse models of lung adenocarcinoma (LUAD) and hepatocellular carcinoma (HCC). The ultimate goal is to provide new insights into p53 pathways that could inform therapeutic strategies.