Award
National Eye Institute 3R01EY033003-04S1
Development and application of a high-fidelity computational model of diabetic retinopathy hemodynamics: Coupling single-cell biophysics with retinal vascular network topology and complexity
Recipient
Rutgers, The State University of New Jersey
Award Amount
$131,000.00
Ceiling
$131,000.00
Awarded
September 06, 2024
Identifier
3R01EY033003-04S1
A project funded by the National Eye Institute to develop a computational model of diabetic retinopathy hemodynamics, integrating retinal vascular network topology with blood cell biophysics to predict disease progression and identify key pathogenic factors.
Description
This project will develop a high-fidelity computational model to understand the relationship between blood flow in retinal vessels, blood cell properties altered by diabetes, and the development of vascular abnormalities. The model aims to simulate microvascular hemodynamics considering detailed 3D vascular network geometry and blood cell deformation, to predict disease progression and identify pathogenic factors such as tissue hypoxia and nitric oxide loss.