Award
NIH Reporter #3R21NS137986-01A1S1
Epigenetic mechanisms of HAND pathogenesis
Recipient
George Washington University, Washington, DC
Award Amount
$71,609.00
Ceiling
$71,609.00
Awarded
January 21, 2026
Identifier
3R21NS137986-01A1S1
Research project funded by the National Institute of Neurological Disorders and Stroke to study epigenetic modifications induced by HIV and their role in neuroinflammation associated with HAND, using humanized mice and human brain data.
Description
This project investigates epigenetic mechanisms underlying HIV-associated neurocognitive disorders (HAND) pathogenesis, focusing on neuroinflammation related to HIV infection and Nef EVs. It involves analysis of epigenetic modifications in humanized mice and comparison with human brain data. The project is high risk but offers high reward, aiming to contribute to understanding and potentially mitigating neurocognitive disorders in HIV patients.