Award
National Institute of General Medical Sciences 1R35GM162202-01
Uncovering Fundamental Principles of Feedback Circuits in Transcription Regulation
Recipient
University of California Riverside
Award Amount
$421,524.00
Ceiling
$421,524.00
Awarded
June 22, 2026
Identifier
1R35GM162202-01
The project investigates feedback circuits in gene expression to understand their role in transcription regulation, using experimental and computational methods to uncover principles relevant to biology and therapy.
Description
This research capitalizes on two distinct synthetic circuits in strategically chosen model systems, illuminating the precise molecular mechanisms by which positive and negative feedback loops govern transcriptional dynamics, stabilize phenotypic states, and enable adaptive responses to both environmental and cellular stressors. By integrating cutting-edge experimental methods—including super-resolution live-cell imaging and advanced lineage tracing tools—with robust computational modeling, this study aims to reveal foundational principles of transcriptional feedback regulation with far-reaching implications for cellular biology, synthetic biology, and therapeutic development.