Award
NIH Reporter #5F31AI181514-02
Probing the ribosome-dependent mechanisms of human alphacoronavirus Nsp1
Recipient
Yale University, New Haven, CT
Award Amount
$34,544.00
Ceiling
$34,544.00
Awarded
August 06, 2025
Identifier
5F31AI181514-02
This award funds research at Yale University to study the ribosome-dependent mechanisms of the coronavirus protein Nsp1, aiming to understand its role in disease severity and to develop targeted therapeutics.
Description
The project aims to understand the functions and mechanisms of the major pathogenicity factor Nsp1 in human alphacoronaviruses to explain differences in disease severity and inform therapeutic targets. The research will provide insights into Nsp1 evolution, aid in developing Nsp1-based therapeutics, and prepare for future coronavirus threats.