Award
NIH Reporter #1F31NS139494-01A1
Default Mode Network Inflammation as a Supraspinal Mechanism of Pain Chronification
Recipient
Pennsylvania State University Hershey Medical Center
Award Amount
$36,562.00
Ceiling
$36,562.00
Awarded
July 25, 2025
Identifier
1F31NS139494-01A1
A research project funded by NINDS to study the role of Default Mode Network inflammation in pain chronification using a rat model, focusing on neuroinflammation and connectivity changes in the brain.
Description
This project aims to characterize Default Mode Network (DMN) connectivity in a rat model of peripheral nerve injury to understand pain chronification mechanisms. It explores neuroinflammation in DMN nodes and tests if microglial silencing can reverse changes in DMN connectivity and pain behaviors. The study is funded by the National Institute of Neurological Disorders and Stroke (NINDS) and conducted at Pennsylvania State University Hershey Medical Center.