Award
National Cancer Institute 11294274
Analyzing DNA replication and damage vulnerability in IDH mutant glioma
Recipient
Massachusetts General Hospital
Award Amount
$401,140.00
Ceiling
$401,140.00
Awarded
March 19, 2026
Identifier
11294274
A multi-year research project funded by the National Cancer Institute to study DNA replication and damage vulnerability in IDH mutant gliomas, aiming to develop targeted therapies with reduced systemic toxicities.
Description
The project involves exploring mechanisms of poly(ADP-ribose)-signaling in IDH mutant gliomas, focusing on developing targeted therapies with minimized systemic toxicities. It includes aims to determine how radiation therapy-induced DNA damage interacts with PARG inhibition. The project is a multi-year research effort with a focus on molecular mechanisms and potential clinical translation.