Award
National Institute of Neurological Disorders and Stroke 7F99NS141403-03
Pneumonia-induced microglial activation causes blood-brain barrier breakdown, astrocyte activation, and tau pathology
Recipient
University of South Florida
Award Amount
$34,537.00
Ceiling
$34,537.00
Awarded
December 04, 2025
Identifier
7F99NS141403-03
The project studies how bacterial pneumonia induces microglial activation leading to blood-brain barrier breakdown, astrocyte activation, and tau pathology, which may contribute to dementia and neurovascular dysfunction. It uses mouse models and post-mortem human brain analysis to understand these mechanisms and explore neurovascular and neuroimmune pathways in migraine models.
Description
This project aims to investigate the mechanisms of neurovascular dysfunction caused by pneumonia and its relation to neurodegenerative diseases, utilizing advanced imaging techniques and animal models.