Award
National Institute on Aging 5F30AG082400-03
Mechanism of mitochondria-induced proteostatic signaling and progressive muscle atrophy during aging
Recipient
Upstate Medical University
Award Amount
$54,538.00
Ceiling
$54,538.00
Awarded
July 30, 2025
Identifier
5F30AG082400-03
Research grant to study how mitochondrial protein import stress and ISR activation contribute to muscle wasting during aging, aiming to identify new therapeutic pathways.
Description
This project investigates the molecular mechanisms of mitochondrial stress-induced muscle atrophy, focusing on bioenergetics-independent pathways. It aims to elucidate how mitochondrial protein import stress activates the integrated stress response (ISR) and contributes to muscle wasting during aging.