Award
National Institute on Aging 5R01AG078734-05
Deciphering tau phosphorylation and Abeta/tau strain interactions in Alzheimer’s pathogenesis
Recipient
University of Florida, Gainesville, FL
Award Amount
$448,122.00
Ceiling
$448,122.00
Awarded
June 01, 2026
Identifier
5R01AG078734-05
Research project funded by the National Institute on Aging to study the interaction between tau phosphorylation and amyloid beta in Alzheimer's disease using mouse models and AAV technology.
Description
The project investigates the etiologic synergy between Aβ deposition and tau misfolding in Alzheimer’s disease. It aims to identify specific phosphorylation sites on tau protein crucial for this synergy and explore the role of amyloid deposits in tau maturation. The research will utilize AAV technology to generate tau phospho-mimetic variants in mouse models, examining how different types of Aβ pathology influence tau phosphorylation and aggregation. The work seeks to enhance understanding of the mechanisms driving tau pathology and its interaction with Aβ, contributing to the development of targeted therapies for Alzheimer’s disease.