Award
National Institute of Neurological Disorders and Stroke 5R01NS123120-05
Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems
Recipient
Massachusetts Institute of Technology, Cambridge, MA, United States
Award Amount
$362,374.00
Ceiling
$362,374.00
Awarded
May 07, 2026
Identifier
5R01NS123120-05
This award funds the development of a non-human primate model to design and test closed-loop anesthesia delivery systems using propofol and dexmedetomidine, aiming to improve brain state monitoring and anesthetic dosing precision, thereby enhancing patient safety and reducing anesthesia-related side effects.
Description
Closed-loop anesthesia delivery (CLAD) systems are an invaluable, but yet unrealized paradigm that can improve second-to-second brain state monitoring of patients during general anesthesia; provide precise computer-controlled anesthetic dosing; and reduce highly prevalent anesthetic side effects such as post-operative cognitive dysfunction. This project aims to develop a non-human primate model for design and testing of CLAD systems for two widely used anesthetics: propofol and dexmedetomidine, combining pharmacokinetics and pharmacodynamic modeling with modern control theory and artificial intelligence approaches.