Award
National Institute of Allergy and Infectious Diseases 5R01AI158304-04
Bacterial and host factors in the pathogenesis of Lyme neuroborreliosis
Recipient
University of North Dakota, GRAND FORKS, ND, 582027306
Award Amount
$394,855.00
Ceiling
$394,855.00
Awarded
April 18, 2025
Identifier
5R01AI158304-04
Research project funded by NIAID to study bacterial and host factors in Lyme neuroborreliosis, focusing on CNS infection mechanisms and potential therapeutic interventions.
Description
The project aims to contribute to understanding how infection by B. burgdorferi causes disease of the central nervous system, elucidating bacterial factors and host immune responses that contribute to neuroinflammation and pathology. The study will utilize a small animal model to assess bacterial and host factors leading to severe inflammatory CNS involvement and test potential interventions.