Award
National Institute of Allergy and Infectious Diseases 1F30AI197375-01
Mechanisms by which extracellular vesicles released by allografts promote anti-donor immunity
Recipient
University of Pittsburgh at Pittsburgh, Department of Surgery
Award Amount
$55,114.00
Ceiling
$55,114.00
Awarded
April 03, 2026
Identifier
1F30AI197375-01
NIH grant awarded to University of Pittsburgh to study extracellular vesicles from allografts and their role in anti-donor immunity, aiming to develop new therapies and biomarkers for transplantation.
Description
This project aims to investigate how extracellular vesicles (EVs) released by allografts influence immune responses and promote anti-donor immunity in transplantation. The research will focus on characterizing the cellular sources and cargo of graft EVs, and assessing their effects on antigen-presenting cells and T cells in secondary lymphoid tissues using mouse models.