National Institute of Neurological Disorders and Stroke 10833065

White matter protection by inhibitors of glial scar formation in perinatal hypoxia ischemia

Research project funded by NINDS to study and develop therapies to prevent glial scar formation and promote myelination in neonatal white matter injury caused by perinatal hypoxia ischemia, potentially reducing disabilities like cerebral palsy.

Description

This project focuses on cellular and molecular mechanisms of disrupted regeneration and repair of neonatal white matter injury, mediated by formation of a “glial scar” that inhibits normal myelination of the preterm developing human brain after hypoxia-ischemia. The research employs molecular and histopathological approaches to define a novel pathway initiating glial scar formation and tests therapies to block this process, aiming to reduce lifelong disabilities such as cerebral palsy.

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