Award
National Institute of Neurological Disorders and Stroke 1F31NS147423-01
Investigating Neuroprotective Roles of BCAT1 During Hypoxia
Recipient
University of Pennsylvania
Award Amount
$49,538.00
Ceiling
$49,538.00
Awarded
September 22, 2025
Identifier
1F31NS147423-01
The award supports research on the neuroprotective role of BCAT1 enzyme during hypoxia, focusing on its impact on BCAA metabolism and potential therapeutic strategies for neonatal hypoxic brain injury.
Description
This project aims to characterize hypoxia's effects on branched chain amino acid (BCAA) metabolism, epigenetic signatures, and oxidative stress, focusing on BCAT1. The study investigates the neuroprotective role of BCAT1 during hypoxia, with potential implications for therapeutic interventions in neonatal brain injury.