Award
National Institute on Drug Abuse 5R61DA058397-04
Innovative In-Situ Imaging Techniques for the Visualization of CNS associated HIV reservoirs in the Context of Substance Abuse
Recipient
University of Florida
Award Amount
$541,407.00
Ceiling
$541,407.00
Awarded
June 03, 2026
Identifier
5R61DA058397-04
Federal grant awarded to University of Florida to develop imaging techniques for CNS HIV reservoirs in non-human primates, emphasizing substance abuse effects.
Description
This project aims to develop advanced in-situ imaging techniques to visualize HIV reservoirs in the CNS of non-human primates, focusing on novel sanctuary sites such as calvarial bone marrow and CSF-draining lymph nodes. The studies will leverage optical tissue clearing, volumetric imaging, and machine learning analysis to understand the spatial distribution and cell types involved in HIV persistence, especially in the context of substance abuse.