# NIH Reporter #5F30CA298663-02

PROX1-dependent epigenetic regulation of phenotypic plasticity during colorectal cancer metastasis

**Recipient:** Weill Medical College of Cornell University

**Award Amount:** $55,114.00
**Ceiling:** $55,114.00

**Awarded:** July 15, 2026

**Identifier:** 5F30CA298663-02

NIH-funded research at Weill Medical College of Cornell University examining PROX1's role in colorectal cancer metastasis, including its effects on cell plasticity and epigenetic regulation.

### Description

A research project investigating how PROX1-dependent transcriptional and epigenetic programs regulate phenotypic plasticity and lineage identity during colorectal cancer metastasis. The project includes studies of PROX1 perturbation in organoids and examination of epigenetic mechanisms involving the NuRD complex.

[View original record](https://reporter.nih.gov/search/47CiHD0bJ0u2LtDABS0zbg/project-details/11378950)