Award
National Heart, Lung, and Blood Institute 5R01HL151685-05
Molecular Imaging CCR2 Lung Inflammation and Fibrosis
Recipient
Washington University
Award Amount
$710,780.00
Ceiling
$710,780.00
Awarded
January 03, 2025
Identifier
5R01HL151685-05
NIH grant awarded to Washington University for developing and evaluating molecular imaging and targeted therapies for pulmonary fibrosis using PET imaging of CCR2+ cells.
Description
This project addresses the challenge of caring for patients with idiopathic pulmonary fibrosis (IPF), a lung disease with short survival and limited therapeutic options. The research team has developed a radiotracer, 64Cu-DOTA-ECL1i, for PET imaging of CCR2+ monocytes, which are implicated in pulmonary fibrosis. The studies will use mouse models to evaluate molecular therapies targeting CCR2+ cells and assess the potential for monitoring disease activity in humans.