Award
National Heart, Lung, and Blood Institute 5R01HL165423-03
Role of ERK1/2 signaling in SARS-CoV-2 -induced dysregulated immunity and lung pathology
Recipient
Oklahoma State University Stillwater
Award Amount
$487,311.00
Ceiling
$487,311.00
Awarded
July 08, 2026
Identifier
5R01HL165423-03
The award supports research on the role of ERK1/2 signaling in SARS-CoV-2 induced lung injury and dysregulated immunity, aiming to identify therapeutic targets to moderate lung inflammation and improve clinical outcomes.
Description
This project investigates the role of SARS-CoV-2 structural proteins/viral RNA and myeloid cell-intrinsic TLR-ERK1/2 activation in causing excessive lung inflammation and pathology, and tests the therapeutic potential of blocking ERK1/2 signaling to reduce lung pathology and improve protection.