Award
National Institute of Allergy and Infectious Diseases 2R01AI154932-06
Proteasome Targeting for Alloreactive Plasma Cells
Recipient
University of Pennsylvania
Award Amount
$3,810,794.00
Ceiling
$3,810,794.00
Awarded
August 20, 2025
Identifier
2R01AI154932-06
This NIH grant supports research to understand and overcome resistance of long-lived plasma cells to proteasome inhibitors, aiming to improve transplantation and autoimmunity outcomes.
Description
We will evaluate the mechanisms whereby antibody-producing plasma cells succumb to or develop resistance to drugs that inhibit proteasome function. Our results should reveal novel strategies to deplete problematic plasma cells, and hence improve outcomes in transplantation and autoimmunity.