Award
NIH Reporter #5F31AA031877-03
Effects of Ventral Tegmental Area Dopamine Neurons GABA-B Receptor Deletion on Cue-Evoked Relapse and Aversion-Resistant Drinking
Recipient
University of Minnesota, Minneapolis, MN
Award Amount
$37,490.00
Ceiling
$37,490.00
Awarded
July 09, 2026
Identifier
5F31AA031877-03
Research project studying the impact of GABA-B receptor deletion in VTA dopamine neurons on relapse and drinking behavior related to alcohol use disorder.
Description
This project aims to investigate the role of GABAB receptors in VTA dopamine neurons on cue-induced relapse and aversion-resistant drinking, using CRISPR-Cas9 gene editing and intra-VTA microinjections of baclofen. The research will provide insights into neural mechanisms underlying AUD and potential therapeutic targets.