Award
National Institute of General Medical Sciences 1R35GM162024-01
Designing cell-instructive viscoelastic hydrogels to understand and exploit mechanobiology
Recipient
University of Virginia, Charlottesville, VA, United States
Award Amount
$415,171.00
Ceiling
$415,171.00
Awarded
March 12, 2026
Identifier
1R35GM162024-01
Development of biomaterials mimicking dynamic tissue properties to study cell mechanobiology and improve understanding of cell-environment interactions, with implications for disease treatment and tissue regeneration.
Description
This project involves the invention of a hydrogel 3D cell culture platform with photopatterned spatiotemporal control of viscoelasticity and stress relaxation. The research aims to match tissue mechanics, study immune-stromal interactions, and develop bioprinted hydrogels capable of remodeling, to better understand cell-ECM interactions.