Award
National Institute on Aging 1F31AG094300-01
Identifying Global Rejuvenation Mechanisms in Tissues that Reverses Age-Related Phenotypes in Planarians
Recipient
UNIVERSITY OF MICHIGAN AT ANN ARBOR
Award Amount
$43,588.00
Ceiling
$43,588.00
Awarded
August 22, 2025
Identifier
1F31AG094300-01
This award supports research to understand how aging affects tissue homeostasis and how regeneration can reverse age-related tissue decline in planarians using advanced spatial transcriptomics technology.
Description
The project aims to characterize how aging and regeneration in planarians alter cell types and their corresponding expression (mRNA) in microenvironmental niches using Ex-Scope, an ultra-high resolution spatial transcriptomics technology. The research could reveal molecular mechanisms by which regeneration rejuvenates tissue architecture, addressing organ frailty and disease progression linked to dysregulation of tissue homeostasis during aging.