Award
NIH Reporter #5R01HL161696-04
Molecular Neurogenetics of the Brainstem Neuronal Source of Cardioprotective Vagal Outflow
Recipient
Thomas Jefferson University
Award Amount
$571,138.00
Ceiling
$571,138.00
Awarded
September 04, 2025
Identifier
5R01HL161696-04
NIH grant awarded to Thomas Jefferson University for research on brainstem neurons regulating vagal nerve activity to develop cardioprotective therapies, focusing on molecular neurogenetics and microRNA regulation.
Description
This project aims to identify, predict, and control the central brainstem neurons that regulate the activity of the vagus nerve in heart function. The research focuses on the dorsal motor nucleus of the vagus (DMV) and investigates the molecular mechanisms, particularly microRNA regulation, involved in cardioprotection and vagal outflow modulation. The study employs integrated experimental and computational approaches, including high-dimensional data analysis, to uncover druggable targets for heart disease treatment.